diagnostic value of serology versus pathology in diagnosis of helicobacter pylori infection
نویسندگان
چکیده
introduction: helicobacter pylori infection is likely acquired was in childhood. helicobacter pylori is recognized as a cause of gastritis and peptic ulcer. our objective to investigate some noninvasive tests, particularly serum h pylori igg, for the diagnosis of h pylori infection in comparison with the gold-standard invasive test, esophagogastroduodenoscopy with biopsy (histology and rapid urease test). materials and methods: we studied 100 patients (age range: 6-18 years) who underwent esophagogastroduodenoscopy with biopsy (histologic examination) for a suspicious upper gastrointestinal disease, in all of them serum hpylori immunoglobulin g was measured and result of this were compared with those of the gold standard esopahgogastrodudenoscopy with biopsy. results: of 100 patients (60 males, 40 females), 91% had history of gastrointestinal disease and 29% had positive family history for gastrointestinal disease. gastritis, ulcer and erosion were found respectively in 94%, 31%, 34% of patients. rapid urease test, serology and histology were positive respectively in 57%, 23%, and 29% of patients. in comparison with histology sensitivity of serology was 45% and it's specificity was 71%. conclusion: serum hpylori igg test has a low sensitivity and specificity in children in comparison with the gold standard invasive test.
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عنوان ژورنال:
گوارشجلد ۱۴، شماره ۱، صفحات ۲۳-۰
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