diagnostic value of serology versus pathology in diagnosis of helicobacter pylori infection

نویسندگان

seyedmohammadmehdi mir-nasseri

fatemeh yourdkhani

bahar allahverdi

farideh siavoshi

چکیده

introduction: helicobacter pylori infection is likely acquired was in childhood. helicobacter pylori is recognized as a cause of gastritis and peptic ulcer. our objective to investigate some noninvasive tests, particularly serum h pylori igg, for the diagnosis of h pylori infection in comparison with the gold-standard invasive test, esophagogastroduodenoscopy with biopsy (histology and rapid urease test). materials and methods: we studied 100 patients (age range: 6-18 years) who underwent esophagogastroduodenoscopy with biopsy (histologic examination) for a suspicious upper gastrointestinal disease, in all of them serum hpylori immunoglobulin g was measured and result of this were compared with those of the gold standard esopahgogastrodudenoscopy with biopsy. results: of 100 patients (60 males, 40 females), 91% had history of gastrointestinal disease and 29% had positive family history for gastrointestinal disease. gastritis, ulcer and erosion were found respectively in 94%, 31%, 34% of patients. rapid urease test, serology and histology were positive respectively in 57%, 23%, and 29% of patients. in comparison with histology sensitivity of serology was 45% and it's specificity was 71%. conclusion: serum hpylori igg test has a low sensitivity and specificity in children in comparison with the gold standard invasive test.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Helicobacter pylori serology and the diagnosis of H. pylori infection in children.

Serological screening accuracy rate may be dependent on clinical and pathological determinants. The aim of this study was to evaluate the accuracy of Hp serology test (Roche Biomedical Lab., Labcorp), in the diagnosis of Hp infection in 121 children who were seen in the Pediatric Gastoenterology Clinic at the Marshall University Joan C. Edwards School of Medicine in Huntington. Positive serolog...

متن کامل

Comparison of levofloxacin versus clarithromycin efficacy in the eradication of Helicobacter pylori infection

Background: Helicobacter pylori (H.pylori) infection causes multiple upper gastrointestinal diseases but optimal therapeutic regimen which can eradicate infection in all the cases has not yet been defined. This study was designed to evaluate the efficacy of triple levofloxacin-based versus clarithromycin-based therapy. Methods: In this open-label randomized clinical trial study 120 patients ...

متن کامل

Diagnosis of Helicobacter pylori Infection.

Helicobacter pylori infection plays an important role in the pathogenesis of chronic gastritis, peptic ulcer disease and gastric malignancy. A diagnosis of infection is thus an important part of a treatment strategy of many gastrointestinal tract diseases. Many diagnostic tests are available but all have some limitations in different clinical situations and laboratory settings. A single gold st...

متن کامل

Helicobacter pylori. Pathology and diagnostic strategies.

Helicobacter pylori represents one of the most common and medically prominent infections worldwide. Infection with this microaerobic, gram-negative bacterium has been established as an etiologic factor in the development of peptic ulcer disease. In addition, H pylori infection has been associated firmly with the development of gastric neoplasia, including gastric adenocarcinomas and gastric muc...

متن کامل

Diagnostic Accuracy of Polyclonal Stool Antigen for Detection of Helicobacter Pylori Infection in Children

Introduction: Helicobacter pylori infection has various clinical features. One of the most common presentations of this infection is upper abdominal pain. Complications such as gastritis, gastric ulcer, gastric carcinoma and MALT lymphoma mandate early diagnosis of H.P infection by a low cost and non invasive manner. The aim of this study was to evaluate the diagnostic role of H.P stool antige...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
گوارش

جلد ۱۴، شماره ۱، صفحات ۲۳-۰

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023